Probiotics are Benefit for Anti-aging

2023-11-06

Aging is the unavoidable biological event, which associated with several physiological, behavioral, and lifestyle events, but people always do not wish to become old. Though genetic, and environmental factors influence aging, diet and gut microbiota play an influential role in senescence, there are evidences show that aging is associated with changes in the gut microbiota. Often the elderly exhibit a lower diversity of bacterial species in their intestinal microbiota due to changes in drug use, dietary habits, and nutritional intake, changes in the dominant species, reduction in beneficial commensal microbes, and increase in facultative anaerobic bacteria, and a noticeable level of reduction in short-chain fatty acids. Likewise, some studies have been reported that lactobacilli were reduced at later stages of aging. Therefore, a balanced diet, physical activity and probiotics supplementation should anti-aging and extend lifespan. Many recent studies have shown that supplementation of probiotics can extend life. Using Caenorhabditis elegans and microorganisms to explore the anti-aging mechanism is one of the commonly used experimental methods. The lifespan extending ability of centenarian fecal isolate, Lactobacillus salivarius strain FDB89 has been demonstrated using Caenorhabditis elegans, the lifespan of the group consuming the FDB89 strain increased by approximately 11.9% compared to the control group. Lactobacillus gasseri SBT2055 mediated lifespan extension of C. elegans, L. gasseri SBT2055-fed worms showed about 37% of lifespan extension when compared with control. In a strain of senescence-accelerated mice (SAM) supplemented with fermented dairy products containing Lactococcus lactis (H61 108 CFU per ml), the results suggested that the consumption of H61 reduce the loss of bone density, hair loss, and manifestation of skin ulcers. Collectively, the results of the study suggested that H61 could be a potent probiotic for the suppression or delaying of aging-related consequences. Other studies have shown the anti-aging properties of Lactobacillus plantarum HY7714 in humans. The human volunteers with dry skin and skin wrinkles (41-59 y old) were supplemented with L. plantarum HY7714 (1010CFU/day) or placebo for twelve weeks. The probiotic supplementation reduced the skin wrinkle, dehydration, and increased the skin gloss, and skin elasticity after twelve weeks compared to baseline and control. The study primarily stated the anti-skin aging property of L. plantarum HY7714 in humans. 

 

Aging is associated with several complicated biological, environmental, geographical, behavioral processes, and also the strongest risk factor for several chronic diseases. The scientific reports revealed that the gut microbiota plays a critical role in maintaining the host immune system, antioxidant system, cognition, etc. It is known that the probiotics supplementation significantly affects the gut microbiota. Even though some studies described the anti-aging properties of probiotics, the reports on clinical trials are very limited. However, probiotics could be a promising approach to prevent and/or treat diseases in the elderly where traditional treatments have failed. Evidence states that protecting the gut microbial balance during aging is compulsory for healthy late life. Further clinical studies with more individuals and long-term interventions are needed to provide evidence that probiotics have health-promoting properties in the general population of the elderly.

 

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